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DUAVEE® (conjugated estrogens/bazedoxifene) Contraindications

4 CONTRAINDICATIONS

DUAVEE is contraindicated in women with any of the following conditions:

  • Undiagnosed abnormal uterine bleeding
  • Known, suspected, or past history of breast cancer
  • Known or suspected estrogen-dependent neoplasia
  • Active deep venous thrombosis, pulmonary embolism, or history of these conditions
  • Active arterial thromboembolic disease (for example, stroke, myocardial infarction) or history of these conditions
  • Hypersensitivity (for example, anaphylaxis, angioedema) to estrogens, bazedoxifene, or any ingredients
  • Known hepatic impairment or disease
  • Known protein C, protein S, or antithrombin deficiency or other known thrombophilic disorders
  • Pregnancy, as DUAVEE may cause fetal harm [see pregnancy (8.1)].

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